Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 50: 165-171, 1981;
8750-7587/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Capen, R. L.
Right arrow Articles by Wagner, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Capen, R. L.
Right arrow Articles by Wagner, W. W., Jr

Journal of Applied Physiology, Vol 50, Issue 1 165-171, Copyright © 1981 by American Physiological Society

ARTICLES

Diffusing capacity of the lung during hypoxia: role of capillary recruitment

R. L. Capen, L. P. Latham and W. W. Wagner Jr

We have used in vivo microscopy to show that airway hypoxia caused pulmonary capillary recruitment. To determine whether the recruited capillaries add to the surface area for gas exchange, we measured the diffusing capacity of the lung for carbon monoxide before and after inducing recruitment with hypoxia. Diffusing capacity increased during hypoxia. However, some increase in diffusing capacity was expected, since there were fewer oxygen molecules to compete with carbon monoxide for hemoglobin-binding sites. To determine the effect of capillary recruitment alone on diffusing capacity, we held hypoxia constant while infusing a vasodilator to diminish recruitment. Diffusing capacity decreased concomitantly as recruitment diminished. These results indicate that our microscopic observations reflect a widespread recruitment that increases the gas exchange surface area.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
W. A. Baumgartner Jr, E. M. Jaryszak, A. J. Peterson, R. G. Presson Jr, and W. W. Wagner Jr
Heterogeneous capillary recruitment among adjoining alveoli
J Appl Physiol, August 1, 2003; 95(2): 469 - 476.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Toga, H. Okazaki, M. Ishigaki, T. Noguchi, J. Huang, T. Fukunaga, Y. Nagasaka, K. Takahashi, and N. Ohya
Effect of hypoxia on pulmonary blood flow-segmental vascular resistance relationship in perfused cat lungs
J Appl Physiol, March 1, 1998; 84(3): 1003 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
W. Wagner Jr, L. Latham, M. Gillespie, J. Guenther, and R. Capen
Direct measurement of pulmonary capillary transit times
Science, October 22, 1982; 218(4570): 379 - 381.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online