Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 49: 905-909, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Welsh, M. J.
Right arrow Articles by Nadel, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Welsh, M. J.
Right arrow Articles by Nadel, J. A.

Journal of Applied Physiology, Vol 49, Issue 5 905-909, Copyright © 1980 by American Physiological Society

ARTICLES

Fluid transport across the canine tracheal epithelium

M. J. Welsh, J. H. Widdicombe and J. A. Nadel

We measured the rate of fluid movement across the tracheal epithelium of the dog by an electrical method, modified from that originally described by Wiedner (Rev. Sci. Instrum. 47: 775-6, 1976). The base-line volume flow (Jv) from the submucosa to the mucosa was 44 +/- 23 nl.min-1.cm-2 (mean +/- SE; n = 6). In only three of the tissues was the resting Jv significantly greater than zero. Stimulation with 2 X 10(-3) M aminophylline (a drug that we have shown stimulates Cl secretion under short-circuit conditions) increased Jv in all tissues to a mean of 137 +/- 29 nl.min-1.cm-2 (P < 0.001). We also measured the unidirectional fluxes of Cl with the tissue at its spontaneous electrical potential. During the base-line period, the net flux of Cl was not significantly different from zero. During stimulation with aminophylline, Cl secretion increased to a mean of 1.44 +/- 0.50 microneq.cm-2.h-1. Comparison of the stimulated values of Jv and net Cl secretion suggests that fluid secretion by the trachea is isotonic during stimulation with aminophylline.


This article has been cited by other articles:


Home page
 ChestHome page
E. Tagaya, J. Tamaoki, M. Kondo, and A. Nagai
Effect of a Short Course of Clarithromycin Therapy on Sputum Production in Patients With Chronic Airway Hypersecretion*
Chest, July 1, 2002; 122(1): 213 - 218.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Crews, A. E. Taylor, and S. T. Ballard
Liquid transport properties of porcine tracheal epithelium
J Appl Physiol, August 1, 2001; 91(2): 797 - 802.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. X.-Y. Wu, C. Y. C. Lee, S. N. Uyekubo, H. K. Choi, S. J. Bastacky, and J. H. Widdicombe
Regulation of the depth of surface liquid in bovine trachea
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L388 - L395.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C Jiang, W. Finkbeiner, J. Widdicombe, P. McCray Jr, and S. Miller
Altered fluid transport across airway epithelium in cystic fibrosis
Science, October 15, 1993; 262(5132): 424 - 427.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
K. Wrenn, C. M. Slovis, F. Murphy, and R. S. Greenberg
Aminophylline Therapy for Acute Bronchospastic Disease in the Emergency Room
Ann Intern Med, August 15, 1991; 115(4): 241 - 247.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
N. S. Hill
The Use of Theophylline in 'Irreversible' Chronic Obstructive Pulmonary Disease: An Update
Arch Intern Med, December 1, 1988; 148(12): 2579 - 2584.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online