Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 49: 897-904, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castile, R. G.
Right arrow Articles by Rodarte, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castile, R. G.
Right arrow Articles by Rodarte, J. R.

Journal of Applied Physiology, Vol 49, Issue 5 897-904, Copyright © 1980 by American Physiological Society

ARTICLES

Determinants of maximal expiratory flow and density dependence in normal humans

R. G. Castile, R. E. Hyatt and J. R. Rodarte

There is a large variability in maximal expiratory flow (V) and density dependence (DD) in normal humans. Lung mechanics and flow-volume curves were obtained in 40 normal males while they breathed air or helium-oxygen (80%-20%). Static lung recoil (Pst) at 50% vital capacity, total lung capacity, and pulmonary resistance each correlated (P < 0.05) with airflow at 50% vital capacity. The relationship of V and Pst was described by Pst = 1/2 p V2/A2 + RV, where p is gas density, A is the critical area at the flow-limiting site, and R is peripheral resistance. At constant Pst and R, this simplified equation predicts an inverse relation between DD and airflow, which was found at recoil pressures of 8 and 7 cmH2O (P < 0.05). If peripheral losses are small, subjects with smaller flow-limiting airways would have lower airflows but higher DD than subjects with larger airways. Our findings are consistent with concept of dysanaptic growth and suggest that the central airways play a significant role in determining V and DD in normal humans.


This article has been cited by other articles:


Home page
 ChestHome page
R. Torchio, C. Gulotta, A. Perboni, C. Ciacco, M. Guglielmo, F. Orlandi, and J. Milic-Emili
Orthopnea and Tidal Expiratory Flow Limitation in Patients With Euthyroid Goiter
Chest, July 1, 2003; 124(1): 133 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Davis, M. Jones, J. Kisling, R. Castile, and R. S. Tepper
Density dependence of forced expiratory flows in healthy infants and toddlers
J Appl Physiol, November 1, 1999; 87(5): 1796 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
Y. Chen
Genetics and pulmonary medicine bullet 10: Genetic epidemiology of pulmonary function
Thorax, September 1, 1999; 54(9): 818 - 824.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. HENSCHEN and J. STOCKS
Assessment of Airway Function Using Partial Expiratory Flow-Volume Curves . How Reliable are Measurements of Maximal Expiratory Flow at FRC during Early Infancy?
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 480 - 486.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online