Journal of Applied Physiology, Vol 49, Issue 5 809-814, Copyright © 1980 by American Physiological Society

ARTICLES

Autonomic mechanisms in the initial heart rate response to standing

D. J. Ewing, L. Hume, I. W. Campbell, A. Murray, J. M. Neilson and B. F. Clarke

Autonomic mechanisms underlying the initial heart rate response to standing were analyzed in nine normal subjects. The normal pattern of response was altered by atropine to a small and gradual R-R interval shortening over 30 beats, with no rebound R-R interval lengthening. With additional propranolol, R-R interval shortening was even less and confined to the first 15-20 beats, whereas propranolol alone did not affect the normal response pattern, showing that this is under vagal control with increased cardiac sympathetic activity occurring only if the vagus is blocked. The response was reproducible in 23 normal subjects. Heart rate variation during quiet standing was almost completely abolished by atropine, but unaffected by propranolol, confirming that it is also under vagal control. In four normal subjects no rebound R-R interval lengthening occurred during either "fast" or "slow" tilt, whereas it was present during both "slow" and "fast" standing. The rebound R-R interval lengthening is determined by the muscular activity involved in standing up, rather than by the speed of the maneuver.

This article has been cited by other articles:

				K. Martinmaki, H. Rusko, S. Saalasti, and J. Kettunen Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2582 - H2589. [Abstract] [Full Text] [PDF]

				S. Motte, M. Mathieu, S. Brimioulle, A. Pensis, L. Ray, J.-M. Ketelslegers, N. Montano, R. Naeije, P. van de Borne, and K. M. Entee Respiratory-related heart rate variability in progressive experimental heart failure Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1729 - H1735. [Abstract] [Full Text] [PDF]

				R. Barbieri, E. C. Matten, A. A. Alabi, and E. N. Brown A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H424 - H435. [Abstract] [Full Text] [PDF]

				E. Toledo, O. Gurevitz, H. Hod, M. Eldar, and S. Akselrod Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1079 - R1091. [Abstract] [Full Text] [PDF]

				R. P. Sloan, E. Bagiella, P. A. Shapiro, J. P. Kuhl, D. Chernikhova, J. Berg, and M. M. Myers Hostility, Gender, and Cardiac Autonomic Control Psychosom Med, May 1, 2001; 63(3): 434 - 440. [Abstract] [Full Text] [PDF]

				D. Roach, R. Haennel, M. L. Koshman, and R. Sheldon Origins of heart rate variability: relationship of heart rate burst morphology to work duration and load Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1491 - H1497. [Abstract] [Full Text] [PDF]

				D. Roach, P. Malik, M. L. Koshman, and R. Sheldon Origins of Heart Rate Variability : Inducibility and Prevalence of a Discrete, Tachycardic Event Circulation, June 29, 1999; 99(25): 3279 - 3285. [Abstract] [Full Text] [PDF]

				J. SIEBERT, J. WTOREK, and J. ROGOWSKI Stroke Volume Variability Cardiovascular Response to Orthostatic Maneuver in Patients with Coronary Artery Diseases Ann. N.Y. Acad. Sci., April 20, 1999; 873(1): 182 - 190. [Abstract] [Full Text] [PDF]

				M P Ingemansson, M Holm, and S B Olsson Autonomic modulation of the atrial cycle length by the head up tilt test: non-invasive evaluation in patients with chronic atrial fibrillation Heart, July 1, 1998; 80(1): 71 - 76. [Abstract] [Full Text]

				A. S. M. Shamsuzzaman, Y. Sugiyama, A. Kamiya, Q. Fu, and T. Mano Head-up suspension in humans: effects on sympathetic vasomotor activity and cardiovascular responses J Appl Physiol, May 1, 1998; 84(5): 1513 - 1519. [Abstract] [Full Text] [PDF]

				P. Bitsios, E. Szabadi, and C.M. Bradshaw The inhibition of the pupillary light reflex by the threat of an electric shock: a potential laboratory model of human anxiety J Psychopharmacol, January 1, 1996; 10(4): 279 - 287. [Abstract] [PDF]

				E. Toledo, I. Pinhas, D. Aravot, Y. Almog, and S. Akselrod Functional restitution of cardiac control in heart transplant patients Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R900 - R908. [Abstract] [Full Text] [PDF]