Journal of Applied Physiology Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 49: 620-626, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lloyd, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lloyd, T. C., Jr

Journal of Applied Physiology, Vol 49, Issue 4 620-626, Copyright © 1980 by American Physiological Society

ARTICLES

Reflex effects of left heart and pulmonary vascular distension on airways of dogs

T. C. Lloyd Jr

Two types of experiments were performed in anesthetized dogs on cardiopulmonary bypass to see if pulmonary vascular congestion and left heart distension would induce reflex bronchoconstriction. First we distended the isolated left heart and lung vessels with blood while ventilating the lungs and measuring airflow, tidal volume, and transpulmonary pressures. Congestion reduced dynamic compliance and increased inspiratory resistance. Vagotomy increased compliance and decreased resistance but did not alter the effects of congestion. Then we measured changes in tracheal wall tension while we separately distended the pulmonary vessels and left heart. Left heart distension increased tracheal tension, whereas pulmonary congestion increased tension in some dogs but decreased it in others. All effects were eliminated by vagotomy. We concluded that although left heart distension and pulmonary vascular congestion may reflexly increase airway tone, pulmonary congestion may at some times reflexly reduce tone. None of these reflex changes, however, appear to be important in the modest (approximately 20%) changes in airflow dynamics observed during combined left heart and pulmonary vascular distension.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. C. H. YAP, D. M. MOORE, J. G. F. CLELAND, and N. B. PRIDE
Effect of Supine Posture on Respiratory Mechanics in Chronic Left Ventricular Failure
Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1285 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Duguet, C. Tantucci, O. Lozinguez, R. Isnard, D. Thomas, M. Zelter, J.-P. Derenne, J. Milic-Emili, and T. Similowski
Expiratory flow limitation as a determinant of orthopnea in acute left heart failure
J. Am. Coll. Cardiol., March 1, 2000; 35(3): 690 - 700.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online