Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 49: 566-570, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cassidy, S. S.
Right arrow Articles by Johnson, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cassidy, S. S.
Right arrow Articles by Johnson, R. L., Jr

Journal of Applied Physiology, Vol 49, Issue 4 566-570, Copyright © 1980 by American Physiological Society

ARTICLES

Hysteresis in the relation between diffusing capacity of the lung and lung volume

S. S. Cassidy, M. Ramanathan, G. L. Rose and R. L. Johnson Jr

The diffusing capacity of the lung for carbon monoxide (DLCO) varies directly with lung volume (VA) when measured during a breath-holding interval. DLCO measured during a slow exhalation from total lung capacity (TLC) to functional residual capacity (FRC) does not vary as VA changes. Since VA is reached by inhaling during breath holding and by exhaling during the slow exhalation maneuver, we hypothesized that the variability in the relation between DLCO and VA was due to hysteresis. To test this hypothesis, breath-holding measurements of DLCO were made at three lung volumes, both when VA was reached by inhaling from residual volume (RV) and when Va was reached by exhaling from TLC. At 72% TLC, DLCO was 22% higher when VA was reached by exhalation compared to inhalation (P < 0.02). At 52% TLC, DLCO was 19% higher when VA was reached by exhalation compared to exhalation (P < 0.005). DCLO measured during a slow exhalation fell on the exhalation limb of the CLCO/VA curve. these data indicate that there is hysteresis in DLCO with respect to lung volume.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
N. MacIntyre, R. O. Crapo, G. Viegi, D. C. Johnson, C. P. M. van der Grinten, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, P. Enright, et al.
Standardisation of the single-breath determination of carbon monoxide uptake in the lung
Eur. Respir. J., October 1, 2005; 26(4): 720 - 735.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. C. W. Hsia
Recruitment of Lung Diffusing Capacity: Update of Concept and Application
Chest, November 1, 2002; 122(5): 1774 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. C. W. Hsia, R. L. Johnson Jr., and D. Shah
Red cell distribution and the recruitment of pulmonary diffusing capacity
J Appl Physiol, May 1, 1999; 86(5): 1460 - 1467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. M. CREAMER, L. L. MCCLOUD, L. E. FISHER, and I. C. EHRHART
Ventilation above Closing Volume Reduces Pulmonary Vascular Resistance Hysteresis
Am. J. Respir. Crit. Care Med., October 1, 1998; 158(4): 1114 - 1119.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online