Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 48: 939-946, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lai-Fook, S. J.
Right arrow Articles by Toporoff, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lai-Fook, S. J.
Right arrow Articles by Toporoff, B.

Journal of Applied Physiology, Vol 48, Issue 6 939-946, Copyright © 1980 by American Physiological Society

ARTICLES

Pressure-volume behavior of perivascular interstitium measured in isolated dog lung

S. J. Lai-Fook and B. Toporoff

Pulmonary perivascular interstitial fluid pressure (Px) was measured as a function of extravascular water accumulation (W). Px was measured directly by wick catheters and open-ended needles inserted in the interstitium near the hilus of isolated perfused dog lobes. Lobes were studied at constant transpulmonary pressure (Ptp) and vascular pressure (Pv, arterial equal to venous pressure). Px-W behavior had two distinct phases: an initial low compliance phase interpreted as perivascular filling, followed sometimes by an abrupt transition to a high compliance phase interpreted as alveolar flooding. W at transition was between 20 and 50% of the initial lung weight. Perivascular compliance during filling at a Ptp of 6 cmH2O was 0.1 g.g wet lobe wt-1.cmH2O-1, which was one-sixth that during alveolar flooding and 2.5 times that at a Ptp of 25 cmH2O. At the start of alveolar flooding, estimated alveolar interstitial fluid pressure was slightly (2 cmH2O) below alveolar pressure (PAlv) at a Ptp of 6 cmH2O but considerably belov PAlv at high lung volumes. These findings support the concept that alveolar surface tension reduces the interstitial fluid pressure below PAlv.


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
A. Duguet, C. Tantucci, O. Lozinguez, R. Isnard, D. Thomas, M. Zelter, J.-P. Derenne, J. Milic-Emili, and T. Similowski
Expiratory flow limitation as a determinant of orthopnea in acute left heart failure
J. Am. Coll. Cardiol., March 1, 2000; 35(3): 690 - 700.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Townsley, K. S. Snell, C. L. Ivey, D. E. Culberson, D. C. Liu, R. K. Reed, and O. Mathieu-Costello
Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure
J Appl Physiol, November 1, 1999; 87(5): 1823 - 1830.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online