Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 48: 1045-1051, 1980;
8750-7587/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grossman, R. F.
Right arrow Articles by Murray, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grossman, R. F.
Right arrow Articles by Murray, J. F.

Journal of Applied Physiology, Vol 48, Issue 6 1045-1051, Copyright © 1980 by American Physiological Society

ARTICLES

Effects of oleic acid-induced pulmonary edema on lung mechanics

R. F. Grossman, J. G. Jones and J. F. Murray

In 25 rabbits anesthetized with pentobarbital sodium and paralyzed with succinylcholine chloride, we investigated the contributions of four factors that might cause the decreased static lung compliance found in oleic acid-induced pulmonary edema: 1) foam, 2) accumulation of fluid in the interstitial spaces, 3) loss of ventilatable units secondary to alveolar flooding, and 4) increased surface tension. Pulmonary edema, reflected by a 115% increase in mean post-mortem extravascular bloodless lung water content, decreased compliance 47% and tripled alveolar-arterial PO2 difference. Removing foam by degassing did not affect compliance measurements. Filling the lungs with saline caused similar changes in control and edematous animals. Because the 38% decrease in functional residual capacity was largely attributable to water accumulation, we concluded that loss of ventilatable units accounted for virtually all the decreased static lung compliance. The role of increased surface tension could not be determined directly but was considered relatively less important.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. L. S. Menezes, P. T. Bozza, H. C. C. Faria Neto, A. P. Laranjeira, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco
Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses
J Appl Physiol, May 1, 2005; 98(5): 1777 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. M. Rocco, A. B. Souza, D. S. Faffe, C. P. Passaro, F. B. Santos, E. M. Negri, J. G. M. Lima, R. S. Contador, V. L. Capelozzi, and W. A. Zin
Effect of Corticosteroid on Lung Parenchyma Remodeling at an Early Phase of Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 677 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S.M. Maggiore, J-C. Richard, and L. Brochard
What has been learnt from P/V curves in patients with acute lung injury/acute respiratory distress syndrome
Eur. Respir. J., August 1, 2003; 22(42_suppl): 22s - 26s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. R. M. ROCCO, E. M. NEGRI, P. M. KURTZ, F. P. VASCONCELLOS, G. H. SILVA, V. L. CAPELOZZI, P. V. ROMERO, and W. A. ZIN
Lung Tissue Mechanics and Extracellular Matrix Remodeling in Acute Lung Injury
Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1067 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. MARTIN-LEFEVRE, J.-D. RICARD, E. ROUPIE, D. DREYFUSS, and G. SAUMON
Significance of the Changes in the Respiratory System Pressure-Volume Curve during Acute Lung Injury in Rats
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. A. MARTYNOWICZ, T. A. MINOR, B. J. WALTERS, and R. D. HUBMAYR
Regional Expansion of Oleic Acid-Injured Lungs
Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 250 - 258.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online