Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 48: 802-811, 1980;
8750-7587/80 $5.00
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Journal of Applied Physiology, Vol 48, Issue 5 802-811, Copyright © 1980 by American Physiological Society

ARTICLES

Phasic changes in bone CO2 fractions, calcium, and phosphorus during chronic hypercapnia

K. E. Schaefer, S. Pasquale, A. A. Messier and M. Shea

The bone CO2 buffering system and bone calcium and phosphorus were studied in guinea pigs exposed to 1% CO2 for periods up to 8 wk and killed at weekly intervals together with control animals of the same age. Measurements were made of arterial CO2 tension, pH, standard bicarbonate, and bone Ca and P. Heat-stabile bone CO2 (carbonate) was determined as dry bone CO2 and heat-labile bone CO2 (bicarbonate) as delta wet-dry bone CO2. During the first 3-4 wk of exposure to 1% CO2, a systemic acidosis was found as indicated in a lowered pH, increased arterial CO2 tension, and decreased standard bicarbonate. The acidosis subsided during the last 4 wk of exposure. Phasic changes in bone bicarbonate were observed as shown in immediate rise lasting for 2 wk followed by a 2-wk decline and second rise after 6 and 8 wk. Bone carbonate exhibited the opposite change during the first 4 wk and thereafter remained stable at an elevated level. Bone Ca and P fell in association with increasing bone bicarbonate and rose with increasing bone carbonate.


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