Journal of Applied Physiology, Vol 48, Issue 2 399-402, Copyright © 1980 by American Physiological Society
Chronic lung lymph fistula in the goat
R. Winn, B. Nadir, J. Gleisner and J. Hildebrandt
Goats have been prepared with chronic lung lymph fistulas in a manner
similar to that described in sheep. Only one thoracotomy is needed to
resect the posterior portion of the caudal mediastinal lymph node and to
cannulate the main efferent duct. Comparison of data from the goat and from
the sheep was accomplished by infusion histamine and by increasing left
atrial and systemic venous pressures. Histamine infusion resulted in an
increase in lymph flow (QL) from a base-line level of 7.3 36 ml/h and an
increase in lymph-to-plasma protein ratio (L/P) FROM 0.70 to 0.82 (n = 2).
In goats subjected to an increase in microvascular pressure averaging 18.2
cmH2O, QL increased from a base line of 6.7 to 23.0 ml/h, while the L/P
decreased by 0.21 (n = 5). Elevation of systemic venous pressure by 8-9
cmH2O did not change QL (n = 4). Thus, the cannulation in the goat is
similar to the sheep in response to induced permeability edema and
hydrostatic edema, and similar with respect to lymph purity tests.
