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J Appl Physiol 48: 16-22, 1980;
8750-7587/80 $5.00
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Journal of Applied Physiology, Vol 48, Issue 1 16-22, Copyright © 1980 by American Physiological Society

ARTICLES

Noradrenergic inhibitory innervation of canine airways

J. A. Russell

The inhibitory innervation of canine airways was examined in isolated trachealis strips and helical strips of airways having outside diameters of 5 and 1.5 mm. Exogenous norepinephrine (10-8 M to 10-3 M) did not alter resting tone but relaxed airways contracted by 10-5 M histamine. Relaxations produced by norepinephrine were antagonized by 10-6 M propranolol, demonstrating the presence of beta-adrenergic receptors. Trans-ural electric stimulation also inhibited contractions produced by histamine. These electrically induced relaxations were blocked by tetrodotoxin and were reduced in magnitude by propranolol, indicating the involvement of a sympathetic neural mechanism. The inhibitory response to electric stimulation was attenuated in airways from catecholamine-depleted dogs and abolished in four of nine catecholamine-depleted airways pretreated with propranolol. Exogenous tyramine (10-5 M) also relaxed histamine-induced contractions, and this effect was blocked by propranolol or catecholamine depletion. The study showed that beta-adrenergic receptors from the trachea to 1.5-mm airways are innervated and that this sympathetic system constitutes the primary inhibitory innervation of airway smooth muscle in the dog.


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