Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 47: 1157-1161, 1979;
8750-7587/79 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferguson, E. W.
Right arrow Articles by Bernier, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferguson, E. W.
Right arrow Articles by Bernier, L. L.

Journal of Applied Physiology, Vol 47, Issue 6 1157-1161, Copyright © 1979 by American Physiological Society

ARTICLES

Fibrinogenolysis and fibrinolysis with strenuous exercise

E. W. Ferguson, C. F. Barr and L. L. Bernier

Twenty healthy young men were exercised on a treadmill according to the protocol of Balke and Ware. Mean duration of exercise was 24.9 +/- 5.7 min and mean maximum heart rate was 195 +/- 9. Fibrinolytic activity was markedly accelerated with euglobulin lysis times decreasing to 36% of control values and fibrinogen-fibrin degradation products increasing 109% after exercise. Assays for fibrin monomer were negative in all samples. In vivo fibrinogen A alpha-chin degradation was assessed by sodium dodecyl sulfate polyacrylamide gel electrophoresis of reduced samples of fibrin monomer isolated by clotting plasma samples in the presence of 0.1 M epsilon-aminocaproic acid and 1% disodium ethylenediaminetetraacetate. The A alpha-chain, the fibrinogen chain most susceptible to plasmin degeneration, showed no evidence of increased degeneration after exercise. Gel scans showed no decrease in the ratio of total alpha-chain to beta- and gamma-chains after exercise. The ratio of intact alpha 1 chain (alpha 1, 67,000 mol wt) to total alpha-chain was 0.66 +/- 0.13 before exercise, 0.64 +/- 0.14 immediately after exercise, and 0.65 +/- 0.13 1 h after exercise. The rate and extent of crosslinking of the alpha-chain of fibrin formed by clotting plasma samples was unaltered by exericse. These data suggest that physiologically significant fibrinogenolysis does not occur with strenuous exercise, even when fibrinolytic activity is markedly accelerated.


This article has been cited by other articles:


Home page
 Br. J. Sports. Med.Home page
J E Smith
Effects of strenuous exercise on haemostasis
Br. J. Sports Med., October 1, 2003; 37(5): 433 - 435.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online