Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 47: 974-977, 1979;
8750-7587/79 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Booth, F. W.
Right arrow Articles by Seider, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Booth, F. W.
Right arrow Articles by Seider, M. J.

Journal of Applied Physiology, Vol 47, Issue 5 974-977, Copyright © 1979 by American Physiological Society

ARTICLES

Early change in skeletal muscle protein synthesis after limb immobilization of rats

F. W. Booth and M. J. Seider

The atrophy of skeletal muscle accruing from disuse, or limb immobilization, is caused by a decreased rate of protein synthesis and an increased rate of protein degradation. Currently, little information is available regarding the initial time of the decline in the rate of protein synthesis in skeletal muscle. The purpose of the present study was to determine, as precisely as possible, the time at which the protein synthesis rate first begins to decline in skeletal muscle, utilizing immobilized limbs of rats for a model. A constant-infusion technique employing [14C]tyrosine was used to estimate protein synthesis rates. During the first 6 h of immobilization, a significant decline of 37% in the fractional rate of protein synthesis from the control level of 5.7%/day was observed. These results suggest that very early changes are occurring in molecular events that regulate protein synthesis in disused or immobilized skeletal muscle.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. K. Powers, A. N. Kavazis, and J. M. McClung
Oxidative stress and disuse muscle atrophy
J Appl Physiol, June 1, 2007; 102(6): 2389 - 2397.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. L. Symonds, R. S. James, and C. E. Franklin
Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivating Cyclorana alboguttata (Gunther 1867)
J. Exp. Biol., March 1, 2007; 210(5): 825 - 835.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
A. Oguro, T. Sakurai, Y. Fujita, S. Lee, H. Kubota, K. Nagata, and Y. Atomi
The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts
Genes Cells, November 1, 2006; 11(11): 1253 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. McClung, J. M. Davis, M. A. Wilson, E. C. Goldsmith, and J. A. Carson
Estrogen status and skeletal muscle recovery from disuse atrophy
J Appl Physiol, June 1, 2006; 100(6): 2012 - 2023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. D. Wang, F. Kawano, Y. Matsuoka, K. Fukunaga, M. Terada, M. Sudoh, A. Ishihara, and Y. Ohira
Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle
Am J Physiol Cell Physiol, April 1, 2006; 290(4): C981 - C989.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Sitnick, A. M. Foley, M. Brown, and E. E. Spangenburg
Ovariectomy prevents the recovery of atrophied gastrocnemius skeletal muscle mass
J Appl Physiol, January 1, 2006; 100(1): 286 - 293.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. Kobayashi, H. Kato, Y. Hirabayashi, H. Murakami, and H. Suzuki
Modulations of Muscle Protein Metabolism by Branched-Chain Amino Acids in Normal and Muscle-Atrophying Rats
J. Nutr., January 1, 2006; 136(1): 234S - 236S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. J. Krawiec, R. A. Frost, T. C. Vary, L. S. Jefferson, and C. H. Lang
Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis
Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E969 - E980.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. C. DeRuisseau, R. A. Shanely, N. Akunuri, M. T. Hamilton, D. Van Gammeren, A. M. Zergeroglu, M. McKenzie, and S. K. Powers
Diaphragm Unloading via Controlled Mechanical Ventilation Alters the Gene Expression Profile
Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1267 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. M. Siu, E. E. Pistilli, and S. E. Alway
Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1015 - R1026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. K. Powers, A. N. Kavazis, and K. C. DeRuisseau
Mechanisms of disuse muscle atrophy: role of oxidative stress
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R337 - R344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. A. Shanely, D. Van Gammeren, K. C. DeRuisseau, A. M. Zergeroglu, M. J. McKenzie, K. E. Yarasheski, and S. K. Powers
Mechanical Ventilation Depresses Protein Synthesis in the Rat Diaphragm
Am. J. Respir. Crit. Care Med., November 1, 2004; 170(9): 994 - 999.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online