Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 47: 1002-1010, 1979;
8750-7587/79 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bachofen, H.
Right arrow Articles by Weibel, E. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bachofen, H.
Right arrow Articles by Weibel, E. R.

Journal of Applied Physiology, Vol 47, Issue 5 1002-1010, Copyright © 1979 by American Physiological Society

ARTICLES

Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent

H. Bachofen, P. Gehr and E. R. Weibel

To assess the influence of alterations of lung surfactant on the geometry of peripheral air spaces, the morphology of detergent-rinsed rabbit lungs was studied. In comparison to normal excised rabbit lungs, fixed in the same manner by vascular perfusion at different points on the deflation pressure-volume curve, the most important differences are as follows. 1) With decreasing lung volume there is a progressive collapse of alveoli; at low lung volume (40% of total lung capacity (TLC) (most alveoli are collapsed, and the air is contained in overextended ducts. 2) Accordingly, the alveolar surface area-to-volume ratio is considerably smaller in particular at medium and low lung volumes. 3) There is only a slight change of mean air-space curvature between 80 and 40% TLC. Hence, the results indicate that in detergent-rinsed lungs volume changes are brought about predominantly by recruitment and derecruitment of alveoli. It appears that both a normal surfactant and the mechanical interdependence within the fibrous continuum are required to maintain a normal respiratory surface area within the lung volume range of normal breathing.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
F. Petak, B. Babik, Z. Hantos, D. R. Morel, J.-C. Pache, C. Biton, B. Suki, and W. Habre
Impact of microvascular circulation on peripheral lung stability
Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L879 - L889.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. P. Butler, R. E. Brown, D. Stamenovic, J. P. Morris, and G. P. Topulos
Effect of surface tension on alveolar surface area
J Appl Physiol, September 1, 2002; 93(3): 1015 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. P. Topulos, R. E. Brown, and J. P. Butler
Increased surface tension decreases pulmonary capillary volume and compliance
J Appl Physiol, September 1, 2002; 93(3): 1023 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. D. Hubmayr
Perspective on Lung Injury and Recruitment: A Skeptical Look at the Opening and Collapse Story
Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1647 - 1653.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. A. Wilson, R. C. Anafi, and R. D. Hubmayr
Mechanics of edematous lungs
J Appl Physiol, June 1, 2001; 90(6): 2088 - 2093.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online