Journal of Applied Physiology
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J Appl Physiol 47: 882-888, 1979;
8750-7587/79 $5.00
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Journal of Applied Physiology, Vol 47, Issue 4 882-888, Copyright © 1979 by American Physiological Society

ARTICLES

Effect of anemia on oxygen transport in hemorrhagic shock

P. O. Malmberg and R. D. Woodson

Effect of anemia on tolerance of hemorrhagic shock in rats was studied to examine opposing effects of altered oxygen capacity and viscosity on oxygen delivery at reduced blood flow. Hematocrit was first reduced by exchange transfusion. Hypotension (BP = 30 Torr) was induced and maintained at this level by controlled hemorrhage; it was terminated when reinfusion of shed blood became necessary to sustain this blood pressure. The period of compensation (time at 30 Torr until reinfusion) in control rats (Hct = 42.5 +/- 2.7%) was 59.23 min; in anemic rats (Hct = 23.3 +/- 2.2%) it was 53 +/- 15 min (SD, P = 0.086). Bleeding rate during shock, mortality, VO2, acid-base balance, and mortality were not influenced by anemia, except for slightly higher lactate in late shock in anemia. The lack of influence of anemia (cf. other perturbations of oxygen transport) was apparently due to a 59-88% increase in cardiac ouput during shock in anemia, which maintained VO2.


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 PerfusionHome page
E. P Hill, D. C Willford, W. Y Moores, R. Bellamy, and W. H Heydorn
Oxygen transport and oxygen consumption vs. cardiac output at different haematocrits
Perfusion, January 1, 1987; 2(1): 39 - 50.
[Abstract] [PDF]


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