Journal of Applied Physiology, Vol 47, Issue 2 257-262, Copyright © 1979 by American Physiological Society

ARTICLES

Cardiac effects of increased lung volume and decreased pleural pressure in man

S. M. Scharf, R. Brown, D. E. Tow and A. F. Parisi

The cardiac effects of increased lung volume and/or decreased intrathoracic pressure were assessed by radionuclide angiography in normal male subjects. Increased lung volume alone produced no change in left ventricular (LV) or right ventricular (RV) end-diastolic size. Decreasing intrathoracic pressure to -30 Torr with a Mueller maneuver led to increases in LV end-diastolic and end-systolic volumes, and to increases in RV diastolic area. LV ejection fraction did not change significantly but RV ejection fraction decreased with the Mueller maneuver. Increases in transmural central venous pressure were also noted with the Mueller maneuver. The effects of combining increased lung volume with the Mueller maneuver were similar to those with the Mueller maneuver alone. These effects are consistent with the hypothesis that producing large negative pleural pressures acts to impede left ventricular outflow (i.e., afterloading) and raises the possibility of similar changes during acute attacks of bronchospasm.

This article has been cited by other articles:

				P O Lundmark, G E Trope, and J G Flanagan The effect of simulated obstructive apnoea on intraocular pressure and pulsatile ocular blood flow in healthy young adults Br. J. Ophthalmol., November 1, 2003; 87(11): 1363 - 1369. [Abstract] [Full Text] [PDF]

				J. Fichter, D. Bauer, S. Arampatzis, R. Fries, A. Heisel, and G. W. Sybrecht Sleep-Related Breathing Disorders Are Associated With Ventricular Arrhythmias in Patients With an Implantable Cardioverter-Defibrillator* Chest, August 1, 2002; 122(2): 558 - 561. [Abstract] [Full Text] [PDF]

				J. Schnader, M. N. Reddy, J. E. Heffner, and S. M. Scharf Clinical Conference On Management Dilemmas* : Obstructive Sleep Apnea And Respiratory Failure Chest, December 1, 1999; 116(6): 1786 - 1793. [Full Text] [PDF]

				L. Shekerdemian and D. Bohn Cardiovascular effects of mechanical ventilation Arch. Dis. Child., May 1, 1999; 80(5): 475 - 480. [Full Text]

				L. S. Shekerdemian, A. Bush, D. F. Shore, C. Lincoln, and A. N. Redington Cardiorespiratory responses to negative pressure ventilation after tetralogy of Fallot repair: a hemodynamic tool for patients with a low-output state J. Am. Coll. Cardiol., February 1, 1999; 33(2): 549 - 555. [Abstract] [Full Text] [PDF]

				S. Boonyaratavej, J. K. Oh, A. J. Tajik, C. P. Appleton, and J. B. Seward Comparison of mitral inflow and superior vena cava Doppler velocities in chronic obstructive pulmonary disease and constrictive pericarditis J. Am. Coll. Cardiol., December 1, 1998; 32(7): 2043 - 2048. [Abstract] [Full Text] [PDF]

				O. P. Mathew Effects of transient intrathoracic pressure changes (hiccups) on systemic arterial pressure J Appl Physiol, August 1, 1997; 83(2): 371 - 375. [Abstract] [Full Text] [PDF]

				L. Chen and S. M. Scharf Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs J Appl Physiol, August 1, 1997; 83(2): 485 - 494. [Abstract] [Full Text] [PDF]