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J Appl Physiol 47: 8-12, 1979;
8750-7587/79 $5.00
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Journal of Applied Physiology, Vol 47, Issue 1 8-12, Copyright © 1979 by American Physiological Society

ARTICLES

Pattern and mechanism of airway response to hypocapnia in normal subjects

C. F. O'Cain, M. J. Hensley, E. R. McFadden Jr and R. H. Ingram Jr

We examined the bronchoconstriction produced by airway hypocapnia in normal subjects. Maximal expiratory flow at 25% vital capacity on partial expiratory flow-volume (PEFV) curves fell during hypocapnia both on air and on an 80% helium- 20% oxygen mixture. Density dependence also fell, suggesting predominantly small airway constriction. The changes seen on PEFV curves were not found on maximal expiratory flow-volume curves, indicating the inhalation to total lung capacity substantially reversed the constriction. Pretreatment with a beta-sympathomimetic agent blocked the response, whereas atropine pretreatment did not, suggesting that hypocapnia affects airway smooth muscle directly, not via cholinergic efferents.


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