Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 46: 669-674, 1979;
8750-7587/79 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baker, J. P.
Right arrow Articles by Younes, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baker, J. P., Jr
Right arrow Articles by Younes, M. K.

Journal of Applied Physiology, Vol 46, Issue 4 669-674, Copyright © 1979 by American Physiological Society

ARTICLES

Graded inspiratory inhibition: specific effects of flow rate

J. P. Baker Jr, J. E. Remmers and M. K. Younes

The effect of inspiratory flow rate on graded inspiratory inhibition was examined in barbiturate-anesthetized paralyzed cats normally ventilated by a phrenic-driven servorespirator. Periodically, the animals were inflated, for a single breath, by a constant-flow volume ramp begun at one of several delays following phrenic onset. The phrenic activity during these volume-ramp test inflations was compared with phrenic activity in the absence of volume feedback. The relation between volume and phrenic inhibition was determined for two different flow rates. Inhibition of phrenic activity began when volume above functional residual capacity (FRC) exceeded a time-dependent threshold and, beyond this threshold, continued in a graded fashion. The threshold for the first detectable inhibition declined as inspiratory time progressed both in intact animals and in pneumotaxic-lesioned animals when phrenic activity reached an apneustic plateau. Inspiratory inhibition was associated with similar lung volume above FRC regardless of whether volume resulted from high or low flow rates, suggesting that the processing of the receptor feedback information offsets flow effects on receptor firing.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
F. LAGHI, J. SEGAL, W. K. CHOE, and M. J. TOBIN
Effect of Imposed Inflation Time on Respiratory Frequency and Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1365 - 1370.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. LAGHI, K. KARAMCHANDANI, and M. J. TOBIN
Influence of Ventilator Settings in Determining Respiratory Frequency during Mechanical Ventilation
Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1766 - 1770.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. FERNANDEZ, M. MENDEZ, and M. YOUNES
Effect of Ventilator Flow Rate on Respiratory Timing in Normal Humans
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 710 - 719.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online