Journal of Applied Physiology
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J Appl Physiol 46: 19-23, 1979;
8750-7587/79 $5.00
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Journal of Applied Physiology, Vol 46, Issue 1 19-23, Copyright © 1979 by American Physiological Society

ARTICLES

Chronic response of rat brain norepinephrine and serotonin levels to endurance training

B. S. Brown, T. Payne, C. Kim, G. Moore, P. Krebs and W. Martin

Norepinephrine (NE) and serotonin (5-HT) concentrations were determined in three areas of the rat brain following 8 wk exposure to differing physical activity and dietary regimens. Animals were divided into sedentary and exercise groups, and one-half of each received either a normal or atherogenic diet. The exercise consisted of 30 min of treadmill running, 5 days/wk, for 8 wk. Brains were weighed and sectioned into cerebral cortex, cerebellum, and remainder (midbrain), and fluorometrically analyzed for NE and 5-HT content. In most brain areas, NE and 5-HT levels were significantly greater among exercise-normal diet and exercise-fat diet compared to both sedentary groups. In the cerebral cortex, exercise-normal diet rats possessed higher levels of NE and lower concentrations of 5-HT than sedentary animals. The atherogenic diet did not affect amine levels other than 5-HT in the cortex among exercise rats. The NE results are consistent with prior research indicating its control of sympathetic function. Increased levels of 5-HT in the midbrain may be the neurotransmittal adaptation responsible for decreased appetite and enhanced weight loss following chronic endurance exercise.


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