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J Appl Physiol 45: 971-977, 1978;
8750-7587/78 $5.00
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Effect of hypercapnia on hypoxic ventilatory drive in carotid body-resected man

George D. Swanson 1, Brian J. Whipp 1, Robert D. Kaufman 1, Kamel A. Aqleh 1, Benjamin Winter 1, and J. Weldon Bellville 1

1 Departments of Anesthesiology, Physiology and Medicine, University of California, Los Angeles, California 90024

Steplike end-tidal hypoxic drives (Petcoco2, = 53 Torr) lasting for 5 min were generated in a group of normal subjects and a group of carotid body-resected subjects when end-tidal CO2, was maintained constant under eucapnic (Petcoco2 = 39 Torr) and hypercapnic (Petcoco2 = 49 Torr) conditions. The hypoxic ventilatory response of the normal subjects was prompt and significant in eucapnia and was enhanced in the hypercapnic state, evidencing CO2-O2 interaction. In contrast, the carotid body-resected subjects did not respond to eucapnic hypoxia but did demonstrate a small but significant ventilatory response to hypoxia against the hypercapnic background. This suggests that the aortic bodies in man may contribute a small component of the hypoxic ventilatory drive under hypercapnic conditions, although the possibility of neuromalike ending regeneration cannot be excluded.

steplike hypoxia; dynamic end-tidal forcing; aortic body function; carotid body resection; ventilatory control

Submitted on May 20, 1977
Accepted on July 23, 1978






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