Journal of Applied Physiology, Vol 45, Issue 6 927-932, Copyright © 1978 by American Physiological Society

ARTICLES

Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation

C. J. Dillard, R. E. Litov, W. M. Savin, E. E. Dumelin and A. L. Tappel

Expired pentane, an index of lipid peroxidation, and pulmonary function were measured as a function of exercise for 1 h with and without exposure to 0.3 ppm ozone. In experiment 1, 10 subjects who exercised on a bicycle ergometer at 50% of maximal oxygen consumption while being exposed to 0.3 ppm ozone had increased lung residual volume and decreased vital capacity, maximal midexpiratory flow rate, and forced expiratory volume in 1 s. In experiment 2, breath collected into a spirometer filled with hydrocarbon-scrubbed air showed increased pentane from the stress of exercise but no effect of ozone. During rest and exercise in experiment 3, two of six subjects had higher pentane levels than the other subjects. Following daily supplementation with 1,200 IU dl-alpha-tocopherol for 2 wk, the mean production of pentane during rest and exercise was significantly lowered, and there was no difference in pentane production among the subjects. It was concluded that lipid peroxidation occurs during exercise and that it is attenuated by vitamin E.

This article has been cited by other articles:

				M. J. Jackson, D. Pye, and J. Palomero The production of reactive oxygen and nitrogen species by skeletal muscle J Appl Physiol, April 1, 2007; 102(4): 1664 - 1670. [Abstract] [Full Text] [PDF]

				J. H. Traverse, Y. E. Nesmelov, M. Crampton, P. Lindstrom, D. D. Thomas, and R. J. Bache Measurement of myocardial free radical production during exercise using EPR spectroscopy Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2453 - H2458. [Abstract] [Full Text] [PDF]

				L. Such, A. Rodriguez, A. Alberola, L. Lopez, R. Ruiz, L. Artal, I. Pons, M. L. Pons, C. Garcia, and F. J. Chorro Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart J Appl Physiol, January 1, 2002; 92(1): 225 - 229. [Abstract] [Full Text] [PDF]

				A. McArdle, D. Pattwell, A. Vasilaki, R. D. Griffiths, and M. J. Jackson Contractile activity-induced oxidative stress: cellular origin and adaptive responses Am J Physiol Cell Physiol, March 1, 2001; 280(3): C621 - C627. [Abstract] [Full Text] [PDF]

				P. M Clarkson and H. S Thompson Antioxidants: what role do they play in physical activity and health? Am. J. Clinical Nutrition, August 1, 2000; 72(2): 637S - 646. [Abstract] [Full Text] [PDF]

				W. J Evans Vitamin E, vitamin C, and exercise Am. J. Clinical Nutrition, August 1, 2000; 72(2): 647S - 652. [Abstract] [Full Text] [PDF]

				C. K Sen and L. Packer Thiol homeostasis and supplements in physical exercise Am. J. Clinical Nutrition, August 1, 2000; 72(2): 653S - 669. [Abstract] [Full Text] [PDF]

				L. M A Heunks and P N R. Dekhuijzen Respiratory muscle function and free radicals: from cell to COPD Thorax, August 1, 2000; 55(8): 704 - 716. [Full Text]

				C. Groussard, I. Morel, M. Chevanne, M. Monnier, J. Cillard, and A. Delamarche Free radical scavenging and antioxidant effects of lactate ion: an in vitro study J Appl Physiol, July 1, 2000; 89(1): 169 - 175. [Abstract] [Full Text] [PDF]

				L. M. A. Heunks, J. Vina, C. L. A. van Herwaarden, H. T. M. Folgering, A. Gimeno, and P. N. R. Dekhuijzen Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1697 - R1704. [Abstract] [Full Text] [PDF]

				J. W. Helge, K. J. Ayre, A. J. Hulbert, B. Kiens, and L. H. Storlien Regular Exercise Modulates Muscle Membrane Phospholipid Profile in Rats J. Nutr., September 1, 1999; 129(9): 1636 - 1642. [Abstract] [Full Text]

				T. M. Best, R. Fiebig, D. T. Corr, S. Brickson, and L. Ji Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits J Appl Physiol, July 1, 1999; 87(1): 74 - 82. [Abstract] [Full Text] [PDF]

				J. M. Lawler, Z. Hu, and W. S. Barnes Effect of reactive oxygen species on K+ contractures in the rat diaphragm J Appl Physiol, March 1, 1998; 84(3): 948 - 953. [Abstract] [Full Text] [PDF]

				K. L. D. De Angelis, A. R. Oliveira, A. Werner, P. Bock, A. Bello-Klein, T. G. Fernandes, A. A. Bello, and M. C. Irigoyen Exercise Training in Aging : Hemodynamic, Metabolic, and Oxidative Stress Evaluations Hypertension, September 1, 1997; 30(3): 767 - 771. [Abstract] [Full Text]