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J Appl Physiol 45: 747-750, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 45, Issue 5 747-750, Copyright © 1978 by American Physiological Society

ARTICLES

Anesthetics inhibit pressure-induced repetitive impulse generation

J. J. Kendig, T. M. Schneider and E. N. Cohen

Repetitive and spontaneous impulse generation appears in nerve axons exposed to high pressure. This phenomenon is a possible basis for high-pressure nervous syndrome (HPNS) or pressure reversal of anesthesia, two examples of an antagonistic interaction between anesthetic drugs and high pressure. In the present study, the interactions between three classes of anesthetic drug (ethyl alcohol, the volatile inhalation agent halothane, and phenobarbital) and repetitive activity were explored. Ethyl alcohol (5% in solution) and halothane (1.3 and 3.4% in oxygen) inhibited pressure-induced repetitive activity. Phenobarbital at 0.25 mM in solution, the maximum concentration obtainable at low temperature, was partially effective. The three drugs produce an unconscious state that is "reversed" at hyperbaric pressure. Halothane and phenobarbital inhibit HPNS, but ethyl alcohol has not been tested for this property. The results thus support a relevance of repetitive activity to HPNS, to pressure reversal of anesthesia, or to both.


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D. K. Mulkey, R. A. Henderson III, R. W. Putnam, and J. B. Dean
Pressure (4 ATA) increases membrane conductance and firing rate in the rat solitary complex</STRONG><BR> J Appl Physiol, September 1, 2003; 95(3): 922 - 930. <BR> <A HREF=[Abstract] [Full Text] [PDF]


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