Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol 45: 463-468, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 45, Issue 3 463-468, Copyright © 1978 by American Physiological Society

ARTICLES

Role of physical effort in the etiology of rat heatstroke injury and mortality

R. W. Hubbard, W. T. Matthew, R. E. Criss, C. Kelly, I. Sils, M. Mager, W. D. Bowers and D. Wolfe

A total of 171 untrained, unacclimatized, and unanesthetized rats were used to evaluate the effects of sedentary and work-induced hyperthermia on the incidence of mortality and cellular injury, 24 h postexposure. Cellular injury was defined as serum transaminase activity (SGPT and SGOT) exceeding 1,000 IU/l (heatstroke levels). Both the percent mortality and the percentage of 24-h survivors with transaminase levels above 1,000 IU/l were plotted against maximum core temperatures. Exertion-induced hyperthermia produced a significantly higher incidence of cellular injury and heatstroke death at lower core temperatures than hyperthermia alone. With hyperthermia only, the SGPT and SGOT dose-response curves were identical. When work was combined with hyperthermia, there was a greater incidence of elevated SGOT at lower core temperatures. These curves bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans. The results suggest a direct role of physical effort in causing heatstroke injury and mortality.


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