| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 44, Issue 5 763-769, Copyright © 1978 by American Physiological Society
ARTICLES |
E. B. Olson Jr and J. A. Dempsey
Oxygen uptake (VO2), expired volume (VE), and arterial blood gases were studied in awake, unrestrained rats over 14 days of hypobaric hypoxia (4,300 m altitude) and upon return to acute normoxia. Control data (at 250 m) showed (mean +/- 95% confidence limits (CL)) arterial oxygen pressure (Pao2) = 85.5 +/- 1.1; arterial carbon dioxide pressure (PaCO2) = 39.8 +/- 0.5; arterial pH pHa) = 7.430 +/- 0.009; VE = 78 +/- 3; VO2 = 2.36 +/- 0.09 ml.min-1.100 g-1; and dead space volumetidal volume ratio (VD/VT) = 0.37 +/- 0.04. During 14 days at 4.300 m the rat showed: a) a constant PaO2 (50-52 Torr); b) a time-dependent hyperventilation (e.g., PaCO2 = 30.2 +/- 1.1 at 1 h of hypoxia, 24.7 +/- 1.3 at day and 21.9 +/- 1.0 at 14 days); c) an increase in VE (85% of control) due to both frequency (33%) and VT (40%); d) a continued but reduced hyperventilation upon acute return to normoxia after 5 h to 14 days at 4,300 m; e) a 24% fall in VO2 after 1 h of hypoxia which returned to control by 4 days at 4,300 m; and f) a rise in pHa to 7.52 after 5 h of hypoxia, which fell to 7.45 by 14-day hypoxia. The rat's marked ventilatory response and changing VO2 during acute hypoxia clearly differs from the human response to sojourn at 4,300 m. However, the progressive and sustained hypocapnia during hypoxic exposure and the continued hyperventilation with acute normoxia in the rat provided essential, perhaps unique characteristics for an animal model of human ventilatory acclimatization.
This article has been cited by other articles:
|
|
 |
|
  R. El Hasnaoui-Saadani, R. C. Alayza, T. Launay, A. Pichon, P. Quidu, M. Beaudry, F. Leon-Velarde, J. P. Richalet, A. Duvallet, and F. Favret Brain stem NO modulates ventilatory acclimatization to hypoxia in mice J Appl Physiol, November 1, 2007; 103(5): 1506 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead Neonatal maternal separation induces sex-specific augmentation of the hypercapnic ventilatory response in awake rat J Appl Physiol, April 1, 2007; 102(4): 1416 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Walsh and J. M. Marshall The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide J. Physiol., August 15, 2006; 575(1): 263 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Walsh and J. M. Marshall The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat J. Physiol., August 15, 2006; 575(1): 277 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. He, J. Chen, B. Dinger, L. Stensaas, and S. Fidone Effect of chronic hypoxia on purinergic synaptic transmission in rat carotid body J Appl Physiol, January 1, 2006; 100(1): 157 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Farias, E. Bustos-Obregon, and J. G. Reyes Increase in Testicular Temperature and Vascularization Induced by Hypobaric Hypoxia in Rats J Androl, November 1, 2005; 26(6): 693 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. He, B. Dinger, and S. Fidone Effect of chronic hypoxia on cholinergic chemotransmission in rat carotid body J Appl Physiol, February 1, 2005; 98(2): 614 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. LaManna, J. C. Chavez, and P. Pichiule Structural and functional adaptation to hypoxia in the rat brain J. Exp. Biol., August 15, 2004; 207(18): 3163 - 3169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat J. Physiol., January 15, 2004; 554(2): 543 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Ilyinsky, G. Tolstykh, and S. Mifflin Chronic hypoxia abolishes posthypoxia frequency decline in the anesthetized rat Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1322 - R1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Reeves, E. Gozal, S. Z. Guo, L. R. Sachleben Jr., K. R. Brittian, A. J. Lipton, and D. Gozal Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat J Appl Physiol, November 1, 2003; 95(5): 1767 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Ray, A. J. Roberts, S. D. Lee, G. A. Farkas, C. Michlin, D. I. Rifkin, P. T. Ostrow, and J. A. Krasney Exercise delays the hypoxic thermal response in rats J Appl Physiol, July 1, 2003; 95(1): 272 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Iioka, K. Tatsumi, K. Sugito, T. Moriya, and T. Kuriyama Effects of insulin-like growth factor on nitrogen balance during hypoxic exposure Eur. Respir. J., August 1, 2002; 20(2): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, L. He, B. Dinger, L. Stensaas, and S. Fidone Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia Am J Physiol Lung Cell Mol Physiol, June 1, 2002; 282(6): L1314 - L1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, L. He, B. Dinger, L. Stensaas, and S. Fidone Chronic hypoxia upregulates connexin43 expression in rat carotid body and petrosal ganglion J Appl Physiol, April 1, 2002; 92(4): 1480 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Olson Jr., C. J. Bohne, M. R. Dwinell, A. Podolsky, E. H. Vidruk, D. D. Fuller, F. L. Powell, and G. S. Mitchel Ventilatory long-term facilitation in unanesthetized rats J Appl Physiol, August 1, 2001; 91(2): 709 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kinkead, L. Dupenloup, N. Valois, and R. Gulemetova Stress-induced attenuation of the hypercapnic ventilatory response in awake rats J Appl Physiol, May 1, 2001; 90(5): 1729 - 1735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bishop, G. Silva, J. Krasney, H. Nakano, A. Roberts, G. Farkas, D. Rifkin, and D. Shucard Ambient temperature modulates hypoxic-induced changes in rat body temperature and activity differentially Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1190 - R1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Alea, M. A. Czapla, J. A. Lasky, N. Simakajornboon, E. Gozal, and D. Gozal PDGF-beta receptor expression and ventilatory acclimatization to hypoxia in the rat Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1625 - R1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bishop, G. Silva, J. Krasney, A. Salloum, A. Roberts, H. Nakano, D. Shucard, D. Rifkin, and G. Farkas Circadian rhythms of body temperature and activity levels during 63 h of hypoxia in the rat Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1378 - R1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Huey, M. J. Low, M. A. Kelly, R. Juarez, J. M. Szewczak, and F. L. Powell Ventilatory responses to acute and chronic hypoxia in mice: effects of dopamine D2 receptors J Appl Physiol, September 1, 2000; 89(3): 1142 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Mortola and E. L. Seifert Hypoxic depression of circadian rhythms in adult rats J Appl Physiol, February 1, 2000; 88(2): 365 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Dwinell and F. L. Powell Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats J Appl Physiol, August 1, 1999; 87(2): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
