Journal of Applied Physiology
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J Appl Physiol 44: 738-742, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 44, Issue 5 738-742, Copyright © 1978 by American Physiological Society

ARTICLES

Distribution of pulmonary responsiveness to aerosol histamine in dogs

J. R. Snapper, J. M. Drazen, S. H. Loring, W. Schneider and R. H. Ingram Jr

Dose-response curves to aerosol histamine in 102 anesthetized, intubated, spontaneously breathing dogs revealed a spectrum of airway responsiveness with a greater than 40-fold difference between the most and the least sensitive animals. The frequency distribution of responses fits a log normal distribution. No correlation was found between sex, age, or control values of dynamic compliance (Cdyn) and lung resistance (RL) and the dose of histamine required to cause a response. Repetitive studies in 17 dogs observed for up to 20 mo showed that the dose at which an individual dog would respond was reproducible within a narrow range and that the differences between dogs were highly significant (P greater than 0.001). The long-term reproducibility of the response to aerosol histamine in individual dogs suggests that short-term reversible airway insults are not responsible for the range in responses noted between animals.


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