Journal of Applied Physiology
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J Appl Physiol 44: 327-332, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 44, Issue 3 327-332, Copyright © 1978 by American Physiological Society

ARTICLES

Sympathetic influence on alveolar surface activity in hyperventilated dog

T. Kobayashi, S. Kishizuchi and S. Murakami

Hyperventilating IPPB, defined as intermittent positive-pressure breathing with a frequency of 32 beats/min and inspiratory pressure of 30 cmH2O, was administered for 14 h to open-chested anesthetized dogs in which nerves to one bronchus were operatively blocked. In the nerve-intact lungs, the lung stability index calculated from the pressure-volume relationship decreased with the duration of the hyperventilating IPPB (correlation coefficient r = -0.66, P less than 0.001), and atelectasis and hemorrhage appeared. In the nerve-blocked lungs, the index did not decrease during the 14 h of hyperventilating IPPB, and the appearance was almost normal. After pharmacologic sympathetic block with phenoxybenzamine, the lung stability index of both the operatively nerve-blocked lung and the nerve-intact lung was not decreased by hyperventilating IPPB. From these findings, we conclude that sympathetic block can protect pulmonary surface activity from the adverse effects of hyperventilating IPPB.




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