Journal of Applied Physiology Millar Instruments
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J Appl Physiol 44: 76-80, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 44, Issue 1 76-80, Copyright © 1978 by American Physiological Society

ARTICLES

Potentiation of hypoxic pulmonary vasoconstriction by ethyl alcohol in dogs

R. C. Doekel, E. K. Weir, R. Looga, R. F. Grover and J. T. Reeves

Pulmonary and systemic hemodynamics and arterial blood gases were measured in anesthetized and mechanically ventilated dogs before and after oral or intravenous administration of ethanol. Increases in mean pulmonary artery pressure and pulmonary vascular resistance occurred. Platelet antiserum-induced thrombocytopenia inhibition of prostaglandin synthesis with meclofenamate, or alpha-adrenergic blockade did not alter the pulmonary pressor response to ethanol. However, the increase in resistance following ethanol was abolished by hyperoxia and potentiated by hypoxia. Thus, it appears that the effect of ethanol is to augment hypoxic pulmonary vasoconstriction, whereas ethanol per se has no independent pulmonary pressor activity.


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 Arch Intern MedHome page
S. A. Sahn, C. H. Scoggin, and B. Chernow
Moderate Alcohol Dose and Chronic Obstructive Pulmonary Disease: Not a Cause of Hypoventilation
Arch Intern Med, April 1, 1979; 139(4): 429 - 431.
[Abstract] [PDF]


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