Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 44: 104-108, 1978;
8750-7587/78 $5.00
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Journal of Applied Physiology, Vol 44, Issue 1 104-108, Copyright © 1978 by American Physiological Society


ARTICLES

Adrenocortical function in response to myocardial necrosis in exercise-trained rats

J. A. Severson, R. D. Fell and D. R. Griffith

Plasma corticosterone concentrations and in vitro adrenal secretion of corticosterone was determined in exercise-trained rats. Virgin, male rats, 100 days of age, were trained for an 11-wk period by treadmill running. Following the training program, rats were subjected to two subcutaneous injections of l-isoproterenol 24 h apart and killed 24 h after the second injection. All exercise-trained rats survived isoproterenol treatment, while 44% of the control rats died. Plasma corticosterone concentrations were elevated only in exercise-trained rats treated with isoproterenol. Control rats treated with isoproterenol had plasma corticosterone concentrations similar to that in control and exercise-treated rats given placebo injections. Exercise training reduced adrenocortical responsiveness to ACTH in vitro, but isoproterenol treatment increased in vitro responsiveness to ACTH in exercise-trained and control rats. Total unstimulated corticosterone secretion rates in vitro were similar. The reason for better rat survival in exercise-trained rats is unknown; however, improved energy metabolism, depressed aldosterone secretion, or both are suggested as reasons for the better survival of exercise-trained rats.





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