Journal of Applied Physiology AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 43: 770-777, 1977;
8750-7587/77 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gilbert, T. M.
Right arrow Articles by Blatteis, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gilbert, T. M.
Right arrow Articles by Blatteis, C. M.

Journal of Applied Physiology, Vol 43, Issue 5 770-777, Copyright © 1977 by American Physiological Society

ARTICLES

Hypothalamic thermoregulatory pathways in the rat

T. M. Gilbert and C. M. Blatteis

The cutaneous blood flow (mbl), rate of oxygen consumption (Vo2), rectal (Tre) and cutaneous (Tsk) temperatures, and shivering activity were measured in unanthetized male rats during a 2-h exposure to 26, 33, or 5 degrees C 2 wk after selective bilateral hypothalamic microknife cuts. Animals with preoptic-anterior hypothalamic (PO/AH) junction cuts 1.5 or 3.0 mm lateral to the midline, as well as parasagittal cuts which separated connections between the PO/AH and medial forebrain bundle exhibited a higher mbl at 26 degrees C than did sham-operated rats. At 5 degrees C the extended (3.0 mm) PO/AH cuts as well as the parasagittal cuts prevented cutaneous vasoconstriction but had no effect on shivering activity; hence Tre was not maintained. None of the cuts demonstrably impaired thermoregulation in the 33 degrees C environment. These results suggest that different sites in the hypothalamus may separately control cold-induced skin vasoconstriction and shivering activity, as well as heat-induced skin vasodilation. It would seem therefore that the integrity of the PO/AH is indispensable in rats for cold-induced cutaneous vasoconstriction but not for cold thermogenesis, and also not for heat-induced cutaneous vasodilation.


This article has been cited by other articles:


Home page
 Postgrad. Med. J.Home page
J E Alty and H L Ford
Multi-system complications of hypothermia: a case of recurrent episodic hypothermia with a review of the pathophysiology of hypothermia
Postgrad. Med. J., June 1, 2008; 84(992): 282 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. G. Tankersley, R. Irizarry, S. E. Flanders, R. Rabold, and R. Frank
Unstable heart rate and temperature regulation predict mortality in AKR/J mice
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R742 - R750.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
H. Kawabe, O. U. Lopes, K. B. Brosnihan, T. Saruta, and C. M. Ferrario
Angiotensin II Pressor Activity Depends on Medial and Lateral Anterior Hypothalamic Pathways
Angiology, August 1, 1995; 46(8): 641 - 648.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online