Journal of Applied Physiology, Vol 43, Issue 4 662-667, Copyright © 1977 by American Physiological Society

ARTICLES

Potentiation of pulmonary vasoconstrictor response with repeated intermittent hypoxia

M. Unger, M. Atkins, W. A. Briscoe and T. K. King

To determine the consistency of the pulmonary vasoconstrictor response to hypoxia, dogs were anesthetized, intubated, and ventilated alternately with air and 10% oxygen. Catheters were placed in the pulmonary artery for measurement of pulmonary artery pressure (PAP), pulmonary capillary wedge pressure, and cardiac output and in the femoral artery for monitoring systemic blood pressure and arterial blood gases. Arterial PCO2 and pH were kept at steady levels throughout by ventilating the dogs with a respirator so that only the isolated effect of hypoxia on the pulmonary vasculature was studied. It was found that there was a progressive rise in the PAP with repeated exposure to the same hypoxic stimulus. In 12 dogs, the mean increase in the PAP was 28% above the base line on the 1st hypoxic exposure, rising to 99% by the 10th exposure over the course of 5 h. It was concluded that interpretation of action of agents blocking or enhancing the hypoxic response must take into account this inherent potentiation of the response on repeated exposure to hypoxia.

This article has been cited by other articles:

				N. Claure Automated Regulation of Inspired Oxygen in Preterm Infants: Oxygenation Stability and Clinician Workload Anesth. Analg., December 1, 2007; 105(6S_Suppl): S37 - S41. [Abstract] [Full Text] [PDF]

				W. Johnson, A. Nohria, L. Garrett, J. C. Fang, J. Igo, M. Katai, P. Ganz, and M. A. Creager Contribution of endothelin to pulmonary vascular tone under normoxic and hypoxic conditions Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H568 - H575. [Abstract] [Full Text] [PDF]

				G. Tusman, S. H. Bohm, F. Melkun, D. Staltari, C. Quinzio, C. Nador, and E. Turchetto Alveolar recruitment strategy increases arterial oxygenation during one-lung ventilation Ann. Thorac. Surg., April 1, 2002; 73(4): 1204 - 1209. [Abstract] [Full Text] [PDF]

				N. Claure, T. Gerhardt, R. Everett, G. Musante, C. Herrera, and E. Bancalari Closed-Loop Controlled Inspired Oxygen Concentration for Mechanically Ventilated Very Low Birth Weight Infants With Frequent Episodes of Hypoxemia Pediatrics, May 1, 2001; 107(5): 1120 - 1124. [Abstract] [Full Text]

				M P Villa, J Pagani, V Lucidi, S Palamides, and R Ronchetti Nocturnal oximetry in infants with cystic fibrosis Arch. Dis. Child., January 1, 2001; 84(1): 50 - 54. [Abstract] [Full Text]

				F. Kerbaul, M. Bellezza, C. Guidon, L. Roussel, M. Imbert, J. P. Carpentier, and J. P. Auffray Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets Br. J. Anaesth., September 1, 2000; 85(3): 440 - 445. [Abstract] [Full Text] [PDF]

				M. L. Fisher and S. C. Body Physiology of One-Lung Ventilation Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 1997; 1(3): 236 - 255. [Abstract] [PDF]