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J Appl Physiol 43: 545-550, 1977;
8750-7587/77 $5.00
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Journal of Applied Physiology, Vol 43, Issue 3 545-550, Copyright © 1977 by American Physiological Society

ARTICLES

Influence of temperature on hemoglobin-ligand interaction in whole blood

M. P. Hlastala, R. D. Woodson and B. Wranne

Temperature-dependent change in hemoglobin-oxygen affinity was measured as a function of hemoglobin-oxygen saturation. In addition, the CO2 Bohr factor and fixed acid Bohr factor were measured as a function of saturation of temperatures of 23, 30, 37, and 44 degrees C. Measurements were made on normal blood and blood with reduced 2,3-diphosphoglycerate (DPG). The influence of temperature is greatest at low saturation and is enhanced slightly by DPG depletion. The CO2 Bohr factor is increased at high temperatures; this is primarily due to increased carbamino formation with rising temperature, especially at lower oxygen saturation. The effect of DPG on oxygen affinity is reduced at a high temperature and elevated at low temperature. These diverse effects of temperature on hemoglobin-ligand interaction require consideration in assessing oxygen delivery when temperature is increased or decreased.




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