Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 42: 809-816, 1977;
8750-7587/77 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hubbard, R. W.
Right arrow Articles by Ratteree, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hubbard, R. W.
Right arrow Articles by Ratteree, J. W.

Journal of Applied Physiology, Vol 42, Issue 6 809-816, Copyright © 1977 by American Physiological Society

ARTICLES

Rat model of acute heatstroke mortality

R. W. Hubbard, W. D. Bowers, W. T. Matthew, F. C. Curtis, R. E. Criss, G. M. Sheldon and J. W. Ratteree

A total of 252 untrained, unacclimatized, and unanesthetized laboratory rats weighing between 485 and 545 g were fasted and either run to exhaustion at 5, 20, 23, or 26 degrees C or were restrained and heated at an ambient temperature of 41.5 degrees C. The incidence of mortality associated with a wide range of work-induced hyperthermias was compared to the lethality of equivalent heat loads in the absence of physical effort. The severity of hyperthermia was calculated in degree-minutes above a base-line core temperature of 40.4 degrees C. The LD25's of run-exhausted versus restrained-heated rats were 16.8 and 30.1 deg-min, respectively. Survivors had a faster cooling rate than fatalities, but run-exhausted survivors had a slower cooling rate than restrained-heating survivors. Results indicate that 1) both the incidence of mortality and the survival time can be predicted from the severity of core heating, 2) work-related factors contribute to an increased rate of heatstroke death at low thermal loads, and 3) retrospectively, both heat-sensitive and heat-resistant groups were identified.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. McClung, J. D. Hasday, J.-r. He, S. J. Montain, S. N. Cheuvront, M. N. Sawka, and I. S. Singh
Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R185 - R191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. L. Lim, G. Wilson, L. Brown, J. S. Coombes, and L. T. Mackinnon
Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R186 - R194.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. C. Lee, H. C. Wen, C. P. Chang, M. Y. Chen, and M. T. Lin
Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke
J Appl Physiol, June 1, 2006; 100(6): 2073 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Bouchama, G. Roberts, F. Al Mohanna, R. El-Sayed, B. Lach, S. Chollet-Martin, V. Ollivier, R. Al Baradei, A. Loualich, S. Nakeeb, et al.
Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke
J Appl Physiol, February 1, 2005; 98(2): 697 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. R. Leon, D. A. DuBose, and C. W. Mason
Heat stress induces a biphasic thermoregulatory response in mice
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R197 - R204.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Sonna, C. B. Wenger, S. Flinn, H. K. Sheldon, M. N. Sawka, and C. M. Lilly
Exertional heat injury and gene expression changes: a DNA microarray analysis study
J Appl Physiol, May 1, 2004; 96(5): 1943 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Prosser, K. Stelwagen, R. Cummins, P. Guerin, N. Gill, and C. Milne
Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders
J Appl Physiol, February 1, 2004; 96(2): 650 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. M. Hall, G. R. Buettner, L. W. Oberley, L. Xu, R. D. Matthes, and C. V. Gisolfi
Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H509 - H521.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Walters, K. L. Ryan, L. M. Tate, and P. A. Mason
Exercise in the heat is limited by a critical internal temperature
J Appl Physiol, August 1, 2000; 89(2): 799 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. M. Hall, K. R. Baumgardner, T. D. Oberley, and C. V. Gisolfi
Splanchnic tissues undergo hypoxic stress during whole body hyperthermia
Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1195 - G1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. P. Lambert, C. V. Gisolfi, D. J. Berg, P. L. Moseley, L. W. Oberley, and K. C. Kregel
Molecular Biology of Thermoregulation: Selected Contribution: Hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress
J Appl Physiol, April 1, 2002; 92(4): 1750 - 1761.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online