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J Appl Physiol 42: 240-244, 1977;
8750-7587/77 $5.00
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Journal of Applied Physiology, Vol 42, Issue 2 240-244, Copyright © 1977 by American Physiological Society

ARTICLES

Cardiac glycogen repletion after exercise: influence of synthase and glucose 6-phosphate

R. K. Conlee and C. M. Tipton

Previous studies have shown that cardiac glycogen content is replenished to supranormal levels after exercise. To better understand this phenomenon glycogen synthase (GS) %I activity as well as glucose 6-phosphate (G-6-P) and glycogen (G) concentrations were measured in hearts from normal and alloxan diabetic rats killed at various time intervals before or after a treadmill run to exhaustion. In normal animals at exhaustion G was reduced but GS %I and G-6-P were elevated. During 2-8 h of recovery G was elevated, %I depressed, and G-6-P unchanged when compared to their preexercise values. By contrast, diabetic hearts that had elevated G and low %I were characterized by abnormally high G-6-P concentrations. At exhaustion in these hearts %I increased significantly in response to a decrease in G. These findings suggest that glycogen repletion occurs in normal heart as a result of the combined increases in GS %I and G-6-P levels present at the cessation of work. In both normal and diabetic hearts there exists an inverse relationship between G content and GS %I activity.


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