Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 41: 874-877, 1976;
8750-7587/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Man, S. F.
Right arrow Articles by Zamel, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Man, S. F.
Right arrow Articles by Zamel, N.

Journal of Applied Physiology, Vol 41, Issue 6 874-877, Copyright © 1976 by American Physiological Society

ARTICLES

Genetic influence on normal variability of maximum expiratory flow-volume curves

S. F. Man and N. Zamel

To determine the importance of genetic influence on the variability of maximum expiratory flow-volume (MEFV) curves in normal individuals, MEFV curves breathing air and a mixture of 80% helium and 20% oxygen (He-O2), lung volumes, specific airway conductance, and closing capacity (CC) were obtained in 10 pairs of identical and 6 pairs of nonidentical twins, all nonsmokers and asymptomatic. For a given pair of identical twins, MEFV curves on air were more similar than those of a pair of nonidentical twins (P less than 0.02). The intrapair differences of identical twins were smaller than nonidentical twins of maximum expiratory flow (Vmax) at 60% of total lung capacity (TLC) on air (P less than 0.001) and on He-O2 (P less than 0.01). However, intrapair differences of Vmax at 40% TLC and CC were not significantly different in the two groups. Since Vmax at 60% TLC on air and He-O2 are dependent on the geometry of large airways these findings are suggestive that the geometry of large airways may be related to genetic factors. The relationship of the geometry of the peripheral airways and genetic factors has not been defined.


This article has been cited by other articles:


Home page
 ThoraxHome page
Y. Chen
Genetics and pulmonary medicine bullet 10: Genetic epidemiology of pulmonary function
Thorax, September 1, 1999; 54(9): 818 - 824.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online