Journal of Applied Physiology, Vol 41, Issue 4 559-564, Copyright © 1976 by American Physiological Society
Drug modification of hypothermia induced by CNS glucopenia in the mouse
M. Mager, S. Robinson and N. Freinkel
2-Deoxy-D-glucose (2-DG), insulin, or norepinephrine (NE), when injected
into the cerebral ventricles of conscious mice, produce decreased rates of
O2 consumption and hypothermia. These changes are accompanied by
hyperglycemia with 2-DG, hypoglycemia with insulin, and normoglycemia with
NE. Desipramine blocks the reduction in body temperature and O2 consumption
produced by each of these agents, but does not modify significantly their
effects on plasma glucose. The latter suggests that the thermal and
oxidative responses to central glucopenia can be dissociated from
concurrent alterations in circulating glucose. Propranolol enhances the
hypothermic response produced by administered 2-DG, insulin, or NE.
Phentolamine, however, antagonizes the hypothermia only with NE, indicating
the 2-DG and insulin are probably not acting through the release of
endogenous NE.
