Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 41: 409-415, 1976;
8750-7587/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Copley, D. P.
Right arrow Articles by Klocke, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Copley, D. P.
Right arrow Articles by Klocke, F. J.

Journal of Applied Physiology, Vol 41, Issue 3 409-415, Copyright © 1976 by American Physiological Society

ARTICLES

Quantitation of right-to-left shunting by double indicator and oxygen techniques

D. P. Copley, R. A. Klocke and F. J. Klocke

An improved double indicator technique for quantitating right-to-left shunting has been validated in a canine right-heart bypass shunt model and compared to standard O2 shunt measurements in the same preparation. A bolus of dissolved sulfur hexafluoride (SF6) and indocyanine green dye (ICG) is injected into systemic venous return and a single, time-averaged arterial blood sample is collected during the initial circulation of indicators. Because of its low solubility, SF6 is eliminated essentially quantitatively from blood traversing gas-filled alveoli; correction for volatile tracer in arterial blood derived from nonshunt pathways in therefore unnecessary. ICG remains confined to the vascular space and SF6 is not lost in shunt pathways. Ratios of SF6-ICG shunt to directly measured shunt averaged 0.99 +/- 0.27 (SD) in 55 comparisons of shunts ranging from 2 to 25% of cardiac output; differences between actual and measured shunt averaged 0.5 +/- 2.9% of cardiac output. Simultaneously determined ratios of O2 shunt to directly measured shunt averaged 0.98 +/- 0.48 in 34 comparisons; differences between actual and measured shunt were 0.7 +/- 3.4% of cardiac output.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. O'Neill, J. G. Venegas, T. Richter, R. S. Harris, J. D. H. Layfield, G. Musch, T. Winkler, and M. F. V. Melo
Modeling kinetics of infused 13NN-saline in acute lung injury
J Appl Physiol, December 1, 2003; 95(6): 2471 - 2484.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online