Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 40: 915-922, 1976;
8750-7587/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frazer, D. G.
Right arrow Articles by Weber, K. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frazer, D. G.
Right arrow Articles by Weber, K. C.

Journal of Applied Physiology, Vol 40, Issue 6 915-922, Copyright © 1976 by American Physiological Society

ARTICLES

Trapped air in ventilated excised rat lungs

D. G. Frazer and K. C. Weber

Degassed excised rat lungs were ventilated in a water-filled plethysmograph with the carina as the zero pressure reference. Pressure-volume curves were recorded from a minimum transpulmonary pressure (Pmin) of -5 cmH2O to a maximum pressure (Pmin) of 30 cmH2O. An index of the minimun volume for the lung (Vm) divided by the maximum lung volume for the same cycle (Vmax) was used as an index of the amount of air trapped within the lung. As the flow rate was decreased from 38.2 to 1.9 ml/min, there were significant increases in the amount of air trapped in the lung. As the maximum pressure was decreased to 25 and 20 cmH2O, or the minimum pressure was increased to 6 and 11 cmH2O, the amount of trapped air in the lung significantly decreased. The rate of lung inflation had a much greater influence on the amount of trapped air than either the deflation rate or stress relaxation. The results are consistent with the theory that bubbles are formed during inflation and are the main cause of air trapped in the excised lung.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. G. Tankersley, J. A. Shank, S. E. Flanders, S. E. Soutiere, R. Rabold, W. Mitzner, and E. M. Wagner
Changes in lung permeability and lung mechanics accompany homeostatic instability in senescent mice
J Appl Physiol, October 1, 2003; 95(4): 1681 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. T. Bates and C. G. Irvin
Time dependence of recruitment and derecruitment in the lung: a theoretical model
J Appl Physiol, August 1, 2002; 93(2): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. TAKEUCHI, K. A. SEDEEK, G. P. P. SCHETTINO, K. SUCHODOLSKI, and R. M. KACMAREK
Peak Pressure During Volume History and Pressure-Volume Curve Measurement Affects Analysis
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1225 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. G. Tankersley, R. Rabold, and W. Mitzner
Differential lung mechanics are genetically determined in inbred murine strains
J Appl Physiol, June 1, 1999; 86(6): 1764 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. G. Tankersley, C. O'Donnell, M. J. Daood, J. F. Watchko, W. Mitzner, A. Schwartz, and P. Smith
Leptin attenuates respiratory complications associated with the obese phenotype
J Appl Physiol, December 1, 1998; 85(6): 2261 - 2269.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online