Journal of Applied Physiology
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J Appl Physiol 40: 844-848, 1976;
8750-7587/76 $5.00
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Journal of Applied Physiology, Vol 40, Issue 5 844-848, Copyright © 1976 by American Physiological Society

ARTICLES

Determing the pulmonary excretion rate of carbon monoxide in newborn infants

C. R. Ostrander, J. D. Johnson and A. L. Bartoletti

A simplified technique was devised for measurement carbon monoxide excretion rates in newborn infants. Determinations can be performed quickly and repetitively in a noninvasive manner, with a sensitivity sufficient for use even on small preterm infants. Resolution of the method is +/- 4.3 mul/h (SD); however, variations in infant respiration rate may cause much greater changes in actual excretion rate. Preliminary results with five full-term newborn agree to within 15% of previously reported data. The system will be used extensively in ongoing studies involving total bilirubin production as a function of gestational age.




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