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J Appl Physiol 40: 648-650, 1976;
8750-7587/76 $5.00
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Journal of Applied Physiology, Vol 40, Issue 4 648-650, Copyright © 1976 by American Physiological Society

ARTICLES

Oral administration of radioactive sulfate to measure extracellular fluid space in man

J. H. Bauer

Radioactive sulfate-35 (35S) was administered to eight human subjects intravenously and orally, to compare respective kinetics of distribution. Intravenously administered 35S attained equilibration within 60-90 min. Orally administered 35S attained equilibration within 60-105 min and thereafter achieved plasma activity equivalent to the intravenously administered tracer. Eighty percent or greater of the 35S dose was recovered in the 24-h urine, following either intravenous or oral administration. The mean extracellular fluid space demonstrated less than 9% mean difference between routes of administration. It is concluded that 35S is completely absorbed at tracer doses, and may be administered orally as a reliable substitute for intravenously administered 35S for measuring extracellular fluid space.


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