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J Appl Physiol 40: 543-548, 1976;
8750-7587/76 $5.00
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Journal of Applied Physiology, Vol 40, Issue 4 543-548, Copyright © 1976 by American Physiological Society

ARTICLES

Canine hyperthermia with cerebral protection

R. W. Carithers and R. C. Seagrave

Extreme whole-body hyperthermia was achieved without lasting side effects in canines by elevating body core temperature to 42 degrees C, using a warm water bath. Cold water irrigation of the nasal alar fold permitted an additional core temperature elevation of 0.5-1.0 degrees C above brain temperature for periods up to 1.5 h. The brain-core temperature differential was maintained by a physiological arteriovenous heat exchanger located at the base of the brain. The maximum tolerable core temperature for the 21 nonirrigated dogs was 42 degrees C for 60-90 min, whereas that for the 28 irrigated dogs was 42.5-43 degrees C for similar time intervals. A mathematical model of the total heat transfer system described the observed dynamic temperature responses. It was the solution of a differential equation which fit the normalized experimental data points and predicted reasonable values for known and unknown experimental parameters.


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