Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 40: 533-538, 1976;
8750-7587/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Souhrada, J. F.
Right arrow Articles by Dickey, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Souhrada, J. F.
Right arrow Articles by Dickey, D. W.

Journal of Applied Physiology, Vol 40, Issue 4 533-538, Copyright © 1976 by American Physiological Society

ARTICLES

Effect of substrate on hypoxic response of pulmonary artery

J. F. Souhrada and D. W. Dickey

Main pulmonary arteries (MPA) were isolated from young guinea pigs and incubated in a modified Krebs-Henseleit solution containing either glucose and sucrose, or sucrose alone. Experimental hypoxia (PO2=30 mmHg) was induced by aerating the muscle chamber with a gas mixture of 95% nitrogen and 5% carbon dioxide. In must experiments the MPA was electrically stimulated, whereas in some no electrical stimulation was used. The isometric tension of electrically stimulated MPA was analyzed by means of resting tension (RT), active tension (ATmax), and maximum rate of tension development (dT/dt). It was demonstrated that when MPA was exposed to acute hypoxia in a glucose-free medium a significant increase in resting tension was observed in both electrically stimulated and nonstimulated preparations. However, the significantly hypoxic response was inhibited by the presence of glucose in the experimental medium. This tonic response of MPA is suggestive of the in vivo hypoxic pressor response of pulmonary circulation. A lower oxygen tension (PO2=95 mmHg) exposure prior to hypoxia significantly potentiated this hypoxic response of the MPA. In a separate series of experiments, isolated aortas demonstrated a similar response when exposed to acute hypoxia in vitro. Similarly, as in experiments with MPA, the presence of glucose inhibited the hypoxic tonic response of isolated aorta.


This article has been cited by other articles:


Home page
 ChestHome page
S. S. Salvi
{alpha}1-Adrenergic Hypothesis for Pulmonary Hypertension
Chest, June 1, 1999; 115(6): 1708 - 1719.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online