Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 40: 338-344, 1976;
8750-7587/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Altose, M. D.
Right arrow Articles by Fishman, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Altose, M. D.
Right arrow Articles by Fishman, A. P.

Journal of Applied Physiology, Vol 40, Issue 3 338-344, Copyright © 1976 by American Physiological Society

ARTICLES

Effects of hypercapnia on mouth pressure during airway occlusion in conscious man

M. D. Altose, S. G. Kelsen, N. N. Stanley, R. S. Levinson, N. S. Cherniack and A. P. Fishman

The effects of hypercapnia and inspiratory flow-resistive loading on mouth pressure during periods of arrested airflow were studied in conscious human subjects to determine the usefulness of inspiratory muscle force in the assessment of respiratory neural efferent activity. Hypercapnia increased the peak end-inspiratory mouth pressure (Ppeak) during complete airway occlusion and the pressures at 100, 200, and 300 ms after the onset of inspiration (P100, P200, P300). During rebreathing without added mechanical loads, P100 and Ppeak increased linearly with the electrical activity of the diaphragm and changes in P100 and Ppeak during hypercapnia correlated well with ventilatory responses to PCO2 (DELTA V/DELTA PCO2) suggesting that occluded mouth pressures are reliable measures of respiratory activity. In individuals with the greatest reduction in delta V/DELTA PCO2 during inspiratory flow-resistive loading, changes in P100 and Ppeak with PCO2 increased only minimally. In contrast, there was a much greater increase in occluded mouth pressures with hypercapnia in the presence of mechanical loading when inspiratory flow-resistive loading failed to depress delta V/DELTA PCO2. In all subjects, occluded mouth pressures were greater at any given PCO2 during mechanical loading than during free breathing. Mechanical loading resulted in augmented respiratory neural efferent activity unexplained by alterations in chemical stimulation.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. M. Dias, C. P. Passaro, V. R. Cagido, M. Einicker-Lamas, J. Lowe, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco
Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling
J Appl Physiol, November 1, 2004; 97(5): 1888 - 1896.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. E. Holliday and C. Veremakis
Reduction in Ventilator Response to CO2 With Relaxation Feedback During CO2 Rebreathing in Normal Adults
Chest, May 1, 1999; 115(5): 1285 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
Y. Kikuchi, S. Okabe, G. Tamura, W. Hida, M. Homma, K. Shirato, and T. Takishima
Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma
N. Engl. J. Med., May 12, 1994; 330(19): 1329 - 1334.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online