Journal of Applied Physiology
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J Appl Physiol 39: 900-905, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 6 900-905, Copyright © 1975 by American Physiological Society

ARTICLES

Pulmonary capillary recruitment during airway hypoxia in the dog

W. W. Wagner Jr and L. P. Latham

To study the effect of hypoxia on the pulmonary capillaries, windows were inserted in the chest wall of 9 pentobarbital-anesthetized dogs. A microscope with an image-superimposing device was used to make drawings of the perfused capillaries. Summed lengths of individual perfused capillaries in the drawing were determined with a map-measuring tool. Total capillary length was constant between PaO2 of 160 and 70 Torr. As PaO2 fell below 70 Torr, recruitment of previously unperfused capillaries occurred in every case; at PaO2 of 40 Torr, the total length of perfused capillaries was about 4 times greater than during normoxia. There was no correlation between the recruitment of capillaries and alterations in left atrial pressure, only a weak correlation with cardiac output changes, but a very strong correlation with increased pulmonary artery pressure. This implies that recruitment was probably caused by vasoconstriction within the lung.


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