Journal of Applied Physiology, Vol 39, Issue 6 1034-1037, Copyright © 1975 by American Physiological Society
Hematological alterations and response to acute hypobaric stress
D. Penney and M. Thomas
Exposure of rats to simulated altitude (15,000 ft) for 1 day and 3 and 9 wk
produced progressive polycythemia, elevated 2,3-diphosphoglycerate levels
and raised P50 values; the latter two parameters decreased toward control
values after 9 wk. Carbon monoxide (38-43% HbCO) exposure produced
polycythemia after 3- and 9-wk exposure, no change in 2,3-DPG and a fall in
P50 value. Ten days' treatment with sodium cyanate produced a large
decrease in 2,3-DPG and P50. Survival during 90 min of acute hypobaria (0.3
atm) under Nembutal anesthesia was highest with NaOCN (75%), intermediate
with 3- and 9-wk exposure to altitude and CO (56-58%) lower in 1-day
altitude exposure (44%) and lowest in controls (5%). Heart and ventilation
rate was monitored during this hypobaric test and response patterns
established for each exposure/treatment. In states of extreme oxygen
deprivation the results suggest, in order of importance, the survival value
of 1) increased oxygen-hemoglobin affinity, and 2) polycythemia.
