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J Appl Physiol 39: 831-833, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 5 831-833, Copyright © 1975 by American Physiological Society

ARTICLES

Myocardial infarction in closed-chest dogs: a simplified method for production

H. A. Lappin, E. H. Botvinick, W. W. Parmley and J. V. Tyberg

Due to our need, we sought a simple method to reliably create myocardial infarction in the closed-chest dog. Previous techniques were dangerous, time consuming, unreliable, and costly. Here we described a new coaxial catheter method by which occluded catheter plugs are embolized selectively to branches of the left coronary artery in closed chest dogs anesthetized with sodium pentobarbital (10 mg/lb). Infarcts varying in size from 3 to 27 g, 2-27% of the left ventricle, were reliably created in dogs weighing 26-70 lb. Complications were rare with only a single fatality in the last 15 procedures. The method proved safe, simple, quick, versatile, reproducible, and inexpensive.




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