Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 39: 735-741, 1975;
8750-7587/75 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by King, R. J.
Right arrow Articles by Creasy, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by King, R. J.
Right arrow Articles by Creasy, R. K.

Journal of Applied Physiology, Vol 39, Issue 5 735-741, Copyright © 1975 by American Physiological Society

ARTICLES

Appearance of paoproteins of pulmonary surfactant in human amniotic fluid

R. J. King, J. Ruch, E. G. Gikas, A. C. Platzker and R. K. Creasy

We have isolated and partially characterized the protein found in surface-active material from adult human lungs, and have determined the time of appearance of this protein in amniotic fluid. Fluids were drawn at gestational ages from 12 to 44 wk, and were assayed for their concentration of apoprotein by an agglutination immunoassay. Surfactant apoprotein ((defined as that protein which is reproducibly found in purified preparations of surface active material) was usually first detected from 30 to 32 wk gestation, and its concentration increased almost fivefold to a maximum at 37 wk. The change in apoprotein concentration was approximately paralleled by the change in phospholipid concentration. At all gestational ages there was wide variability in both phospholipid and apoprotein concentrations, and the time of appearance of the apoprotein in amniotic fluid differed among fetuses. The results suggest that the presence of surfactant apoprotein in amniotic fluid is coincident with the biochemical and morphological maturation of the fetal lung, and are additional evidence that this apoprotein is cosecreted with the lipids of surface-active material.


This article has been cited by other articles:


Home page
 Vet PatholHome page
B. Grubor, D. K. Meyerholz, and M. R. Ackermann
Collectins and cationic antimicrobial peptides of the respiratory epithelia.
Vet. Pathol., September 1, 2006; 43(5): 595 - 612.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. R. KHUBCHANDANI and J. M. SNYDER
Surfactant protein A (SP-A): the alveolus and beyond
FASEB J, January 1, 2001; 15(1): 59 - 69.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online