Journal of Applied Physiology, Vol 39, Issue 4 689-691, Copyright © 1975 by American Physiological Society
Similarity of blood flows using indocyanine prepared in saline or distilled water
L. L. Aarhus and D. E. Donald
Directly measured blood flow pumped through a mixer circuit was compared to
estimates of flow from indicator dilution curves derived from bolus
injections of indocyanine green dye prepared in 0.9% saline (saline dye)
and in triple-distilled water (3 D dye). At flows whose mean appearance
time was 1.6 s, the mean error of estimate +/-SD of 2.3 +/- 5.1% using 3 D
dye was significantly different (P less than 0.05) from that of 5.6 +/-
7.0% using saline dye. Essentially, there was no difference in estimates of
blood flow with each dye solution when mean appearance time was increased
to 3.8 s. Thus, the error, which was perhaps due to electrolyte in the
concentrated indocyanine green dye (saline dye) and subsequent slowed rate
of optical stabilization after dilution in plasma, is small and does not
explain the overestimation by indocyanine dilution curves of blood flow in
intact dogs.
