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J Appl Physiol 39: 648-652, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 4 648-652, Copyright © 1975 by American Physiological Society

ARTICLES

Effect of altitude exposure on platelets

G. W. Gray, A. C. Bryan, M. H. Freedman, C. S. Houston, W. F. Lewis, D. M. McFadden and G. Newell

Since decompression from depth is known to produce a fall in platelet count, the effect of altitude decompression and high-altitude exposure on platelets was investigated. Sixteen subjects decompressed without hypoxia to 20,000 ft simulated altitude for two hours showed a significant (P less than 0.01) drop in circulating platelet count of approximately 10% for three days following decompression. Four of five subjects similarly exposed had a shortened autologous platelet survival compared to that prior to exposure. Subjects exposed to 9,800 ft and then 17,600 ft in a mountain environment showed a significant mean decrease in platelet count on day 2 of 7% and 25% respectively, which had returned to control by day 5. Nonhypoxic and hypoxic decompressed rabbits which received homologous chromium-51-labeled platelets had an increase in lung radioactivity compared with sea-level controls. It is postulated that altitude decompression produces platelet reductions similar to these seen after decompression from depth, and that platelets sequester in the pulmonary vascular bed.


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