Journal of Applied Physiology
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J Appl Physiol 39: 444-448, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 3 444-448, Copyright © 1975 by American Physiological Society

ARTICLES

Maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust

W. J. Moorman, T. R. Lewis and W. D. Wagner

To assess early ventilatory responses at the 2 mg/m3 bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to Pennsylvania and Utah coal dust. Ten controls were utilized. Pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the Utah coal was selected from a low prevalence area. After 24 mo of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. Reductions were observed in the forced expiratory volume in 1 s, maximum midexpiratory flow rate, and especially maximum expiratory flow at small lung volumes. Hyperinflation (RV/TLC) was observed in both coal treatments; however, no specific lung volumes differed significantly from controls. No differences were found between the Pennsylvania and Utah treatments. Design and specifications for a new hydraulically operated plethysmograph-respirator are included.


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