Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 39: 231-234, 1975;
8750-7587/75 $5.00
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Journal of Applied Physiology, Vol 39, Issue 2 231-234, Copyright © 1975 by American Physiological Society

ARTICLES

Relationship between turnover rate and blood concentration of lactate in exercising dogs

F. L. Eldridge

Steady-state blood lactate concentrationss and lactate turnover, or entry, rates were determined by use of constant infusion of L(+)-[14C]lactate in seven anesthetized dogs before and during electrically induced exercise. Lactate entry rates increased during exercise in all dogs with or without the infusion of additional exogenous cold lactate. Blood lactate concentrations, on the other hand, rose to levels considerably below those predicted for these entry rates in a previous study of the relationship in normal nonexercising dogs. It is concluded that improved efficiency of lactate removal during exercise allows low blood concentrations despite large increases in entry rates.


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K. M. Kelley, J. J. Hamann, C. Navarre, and L. B. Gladden
Lactate metabolism in resting and contracting canine skeletal muscle with elevated lactate concentration
J Appl Physiol, September 1, 2002; 93(3): 865 - 872.
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